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    钙离子通道检测

    1.       L-type calcium channel (CaV1.2)Channel Cav1.2/β2/α2/δ1, L-typeCatalog Ref.ICE-CHO-Cav1.2GeneCACNA1CSourceshumanExpression systemCHOMethodwhole cell patch clampRe

    1. 详细信息


    1.  L-type calcium channel (CaV1.2)


    Channel

    Cav1.2/β2/α2/δ1, L-type

    Catalog Ref.

    ICE-CHO-Cav1.2

    Gene

    CACNA1C

    Sources

    human

    Expression system

    CHO

    Method

    whole cell patch clamp

    Reference Inhibitor

    Nifedipine(31.3nM±6.8nM), verapamil

    Target

    Timothy syndrome, long QT syndrome,  Pain, epilepsy, hypertension, stroke, arrhythmia, Autism



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    2N-type calcium channel (CaV2.2)


    Channel

    Cav2.2/β3/α2δ1 , N-type

    Catalog Ref.

    ICE-CHO-Cav2.2

    Gene

    CACNA1B

    Sources

    human

    Expression system

    CHO

    Method

    whole cell patch clamp

    Reference compound

    Nifedipine, verapamil, Cadmium (IC50=7.0µm±704nM)

    Target

    Pain, Spinal cord injury, Kleefstra syndrome



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    3T-type calcium channel (CaV3.2)

     

    Channel

    CaV3.2, T-type

    Catalog Ref.

    ICE-CHO-Cav3.2

    Gene

    CACNA1H

    Sources

    human

    Expression system

    HEK293

    Method

    whole cell patch clamp

    Reference compound

    Nifedipine, verapamil, NiCl

    Target

    Convulsion

     

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    4P/Q-type calcium channel (CaV2.1)


    Channel

    Cav2.1

    Catalog Ref.

    ICE-CHO-Cav2.1

    Gene

    CACNA1A

    Sources

    human

    Expression system

    CHO

    Method

    whole cell patch clamp

    Reference inhibitor

    Cadmium (2.9 ± 0.658µM)

    Target

    migraine, seizure and ataxia syndromes


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