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    钾离子通道检测

    Kv1.1                             ChannelKv1.1 (Shaker)GeneKCNA1SourceshumanExpression systemHEK293Methodwhole cell patc

    1. 详细信息

    Kv1.1

      

    Channel

    Kv1.1 (Shaker)

    Gene

    KCNA1

    Sources

    human

    Expression system

    HEK293

    Method

    whole cell patch clamp

    Standard time

    2 weeks

    Reference compound

    4-AP

    Target

    multiple sclerosis, seizure


      Kv1.3

       

    Channel

    Kv1.3 (Shaw)

    Catalog Reference

    ICE-HEK-Kv1.3

    Gene

    KCNA3

    Sources

    Human

    Expression system

    HEK293

    Method

    whole cell patch clamp

    Standard time

    2 weeks

    Reference compound

    4-AP,

    Target

    cancer, obesity, diabetes, asthma, immune system diseases


    Kv1.5 


    Channel

    Kv1.5

    Gene

    KCNA5

    Sources

    Human

    Catalog Reference

    ICE-HEK-Kv1.5

    Expression system

    HEK293

    Method

    whole cell patch clamp

    Standard time

    2 weeks

    Reference compound

    4-AP (9.9μM±15.0μM)

    Target

    Atrial fibrillation



    blob.pngblob.png    blob.pngblob.png blob.png 

    Kv2.1


    Channel

    Kv2.1

    Gene

    KCNB1

    Sources

    Human

    Catalog Reference

    ICE-HEK-Kv2.1

    Expression system

    HEK293

    Method

    whole cell patch clamp

    Standard time

    2 weeks

    Reference compound

    4-AP

    Target

    Atrial fibrillation



    Kv4.3


    Channel

    KV4.3

    Gene

    KCND3

    Sources

    Human

    Catalog Reference

    ICE-HEK-Kv4.3

    Expression system

    HEK293

    Method

    whole cell patch clamp

    Standard time

    2 weeks

    Reference compound

    4-AP

    Target

    Atrial fibrillation

     

    Kv7.1


    Channel

    KV7.1, KCNQ1/KCNE1, IKs

    Gene

    KCNQ1/KCNE1

    Sources

    Human

    Catalog Reference

    ICE-HEK-Kv7.1

    Expression system

    HEK293

    Method

    whole cell patch clamp

    Standard time

    2 weeks

    Reference compound

    Chromanol 293B

    Target

    QT-prolongation



    blob.png blob.png  blob.pngblob.png  blob.png   blob.png


    Kv7.2/7.3


    Channel

    KV7.2/7.3, KCNQ2/KCNQ3, M current

    Gene

    KCNQ2/KCNQ3

    Sources

    Human

    Catalog Reference

    ICE-HEK-Kv7.2/7.3

    Expression system

    HEK293

    Method

    whole cell patch clamp

    Standard time

    2 weeks

    Reference compound

    Retigabine

    Target

    Epilepsy



     blob.png  blob.png

    Kv7.4


    Channel

    Kv7.4

    Gene

    ICE-HEK-hKCNQ4

    Sources

    Human

    Catalog Reference

    ICE-HEK-Kv7.4

    Expression system

    HEK293

    Method

    whole cell patch clamp

    Standard time

    2 weeks

    Reference compound

    ML213

    Target

    Cochlea


     


    blob.png   blob.png   blob.png 

     

    Kv11.1 (hERG)


    Channel

    KV11.1,hERG,IKr

    Gene

    KCNH2

    Sources

    Human

    Catalog Reference

    ICE-HEK-hERG

    Expression system

    HEK293

    Method

    whole cell patch clamp

    Standard time

    2 weeks

    Reference compound

    E4031, cisapride

    Target

    QT-prolongation, Torsade de Pointe(TdP)

     

      

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